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KMID : 0614620040430020090
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Korean Journal of Gastroenterology
2004 Volume.43 No. 2 p.90 ~ p.95
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The Changes of Matrix Metalloproteinase-9 Expression in the Gastric Antral Mucosa after Helicobacter pylori Eradication: Immunohistochemical Study.
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안혁수/Ahn HS
김인희/이승옥/강명재/김대곤/이수택/Kim IH/Lee SO/Kang MJ/Kim DG/Lee ST
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Abstract
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Background/Aims: In this study, we analysed the changes of matrix metalloproteinase-9 (MMP-9) expression in the gastric antral epithelium in respect to H. pylori eradication.
Methods: Twenty patients with H. pylori-positive chronic gastritis or peptic ulcer were studied. The expression of MMP-9 in the gastric antral biopsy specimens were compared before and after H. pylori eradication using immunohistochemical study. The positive rates and intensity of MMP-9 staining were evaluated at surface mucous cells and pyloric gland cells.
Results: The positive rate of MMP-9 staining in antral mucosal epithelial cells of H. pylori chronic gastritis is 63.8%. The positive rates of MMP-9 staining in the surface mucous cells and pyloric gland cells were 75.5% and 52.0% before H. pylori eradication, respectively. On the contrary, the rates were 85.5% and 82.0% after eradication. The MMP-9 overexpression in the pyloric gland cells were noticeably increased after H. pylori eradication. Strong positive staining of MMP-9 was increased significantly after H. pylori eradication in the pyloric gland cells.
Conclusions: These results suggest that MMP-9 over-expression is associated with H. pylori infection as a host inflammatory response. The increased expression after H. pylori eradication indicates that MMP-9 may have a important role in remodeling or early tissue repairing process of gastric mucosa
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